Analysis of nucleotide-binding oligomerization domain proteins in a murine model of pneumococcal meningitis
نویسندگان
چکیده
منابع مشابه
Analysis of nucleotide-binding oligomerization domain proteins in a murine model of pneumococcal meningitis
BACKGROUND The innate immune system recognizes pathogens via its pattern recognition receptors. The objective of this study was to investigate the role of the nucleotide-binding oligomerization domain (NOD) proteins, a family of the novel bacterial pattern recognition receptors, in host responses to the gram-positive bacteria Streptococcus pneumoniae. METHODS Sprague-Dawley rats were infected...
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Streptococcus (S.) pneumoniae is the most common causative pathogen in community-acquired pneumonia. Nucleotide-binding oligomerization domain-containing (NOD) 2 is a pattern recognition receptor located in the cytosol of myeloid cells that is able to detect peptidoglycan fragments of S. pneumoniae. We here aimed to investigate the role of NOD2 in the host response during pneumococcal pneumonia...
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ژورنال
عنوان ژورنال: BMC Infectious Diseases
سال: 2014
ISSN: 1471-2334
DOI: 10.1186/s12879-014-0648-3